Healthy medicine is forthcoming!

Healthy regimen~ Really?

           150 years ago, parabiotic experiments proved that there is reversion of disease and aging (healthy regimen) !

        In 1878, Claude Bernard first pointed out that the living parts of living organisms exist in the fluids which bathe them

(the internal environment or extracellular fluid) and that all vital mechanisms depend on stable internal environment or homeostasis.

                  Pairing two animals in parabiosis to test for circulatory or systemic factors (extracellular fluid) from one animal affecting the other animal

has been used in scientific research for at least 150 years.  A variation on the above technique, heterochronic parabiosis, whereby old and young

animals are paired to test for systemic regulators or factors of aspects of aging and antiaging also has a century-long scientific history. 

     Parabiosis refers to the condition in which two living animals are connected surgically and develop a single, shared circulatory system.

It has been demonstrated that parabiosis to healthy animals could increase the lifespan of animals that would otherwise die earlier due to

disease or lethal treatment of some sort such as irradiation. When the circulatory systems of old and young animals are joined together

in a heterochronic parabiotic model, the older partner undergoes rejuvenation.  Therefore, current work verify a paradigmof treatment

or reversion of aging and age-related diseases; the age and pathologies of tissues is acutely, rapidly, effectively reversed to younger and healthy states.

       But humans cannot be conjoined.  Therefore, this only effective healthy regimen in the world at this time was put away.

Heart Conditioning ~ Body Conditioning~ Really?

       Stress is a constellation of events, consisting of a stimulus or signal generated by any physical, chemical or biological factors (stressor),

that activates physiological fight or flight systems in the body (stress response) in order to counteract, adapt and survive, which involve

the release of factors in the systemic circulation and locally within central and peripheral tissues.

       Generally speaking, brief, transient and physiological stress activates multiple physiological systems such as cardiovascular,musculoskeletal,

neuroendocrine and immunological systems to enhance body protection or performance.  Such stress adaptive response is one of nature's

fundamental survival mechanisms, or known as self-curative mechanisms.  However,severe, persistent and pathological stress is maladaptive,

and has been shown to have numerous adverse effects on health and longevity.

       Coronary arteries are the blood vessels of the heart.  Heart ischemia occurs when blood supply to the heart muscle is reduced due to

occlusion of the coronary arteries.  Mild, transient, physiological heart ischemia produces adaptive or compensatory mechanisms. 

Severe, sustained, pathophysiological heart ischemia gives rise to maladaptive or decompensatory mechanisms.

In 1986, Murry et.al. first demonstrated ischemic preconditioning in dogs.  Brief repeated occlusions of the coronary artery before the

subsequent sustained occlusion resulted in reductionin infarct size.  Ischemic preconditioning has been reproducibly well established

in all animal species investigated as well as humans.  Ischemic preconditioning is beneficial and protective against postischemic

contractile dysfunction, ischemia- and reperfusion-induced cardiac arrhythmias,apoptosis, and infarct injury.  This shift of the heart to

a preconditioned phenotype (feature) with mild, transient,physiological heart ischemia is recognized as an important progress in the field

of heart protection.

       To recapitulate, by mild, transient, physiological heart ischemia, which is a stress to the heart, compensatory adaptations are induced,

which maintain cardiovascular homeostasis and normal cardiovascular functions, at the molecular, cellular, structural, tissue and organ levels. 

Therefore, the heart can already be conditioned and protected, as demonstrated by the beneficial and protective effects observed following

the subsequent sustained heart ischemia and/or reperfusion.  The heart then becomes less vulnerable to subsequent cardiovascular events. 

Heart conditioning is thus the most important healthy regimen, because it can prevent the most common but fatal diseases of sudden death,

myocardial infarction and stroke, at least reduce the morbidity and mortality.  Besides, a healthy cardiovascular system covers and crosstalk

to all other systems of ourbody.  Heart conditioning not only has protective effects on the heart, but also remote organs such as brain, lung,

kidney or gut, against injuries associated with ischemia and other insults,including toxicants, hemorrhagic shock/resuscitation, and

iodinatedradiocontrast media.  Moreover, it is speculated that, similar to heart conditioning, the other body systems may likewise be stressed,

conditioned and protected.  Hence, evidence that conditioning exists in humans may provide a major impetus to the development of modalities

or measures for keeping the heart and the other body systems in a continuously conditioned and protected state, preferably regularly and indefinitely. 

The response of the body to environmental changes is the fundamental of homeostasis. The human body is capable to recruit various adaptive,

compensatory mechanisms in order to keep body homeostasis and normal function in response to a variety of aggressions or stressors. 

It is becoming increasingly clear that conditioning of the heart and other body systems are stressors which can elicit compensatory

adaptations so as to maintain cardiovascular and body homeostasis,and is an important feature of successful antiaging programs.

Healthy regimen~ Concerning life and living~ Must learn it~ Must practice it~

       Lately, it is established that heart conditioning produces cardioprotective or normal factors.  It has been demonstrated that plasma (extracellular fluid)

from animals subjected to heart conditioning may be used to transfer cardioprotection to other animals and between species, suggesting a protective

(or normal) factor in the circulation.

       Utilizing modern medicine, diet, exercise, lifestyle modification and conditioning of the whole body, so as to implement normal factors and remove

abnormal factors simultaneously, this healthy regimen may therefore lead to reversion of disease and aging, similar to that of the

heterchronic parabiosis model.  In particular, cells are under a mild physiological stress due to conditioning of the body, and the cells

respond to the stress adaptively by restoring homeostasis with normal internal environment or systemic milieu, and enhancing their ability

to cope with stress and maybe, to oppose or reverse disease and aging.  Healthy regimen is the reversion of diseaseand aging,

as demonstrated and evidenced by the heterochronic parabiosis model.

       For details, please study the book “Healthy regimen: Reversion of disease and aging”, or review article (www.heartdisease.idv.tw).

Pursuit of health~  Please read~